Patents

U.S. Patent No. 9,107,887

"Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer",

Eagle, Craig J.; Dees, H. Craig; Wachter, Eric A.; Singer, Jamie

A method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. A further method for the treatment of cancer comprising administration of a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition, or variant of said composition, in combination with a therapeutically effective amount of a systemic targeted anticancer agent. The present invention is further directed to pharmaceutical compositions for treatment of cancer. The intralesional chemoablative pharmaceutical composition can comprise an IL chemoablative agent comprising primarily a halogenated xanthene.

U.S. Patent No. 8,974,363

"Topical medicaments and methods for photodynamic treatment of disease",

Dees, H. Craig; Scott, Timothy C.; Smolik, John; Wachter, Eric A.; Fisher, Walter G.

This patent covers new photodynamic, topically-applicable medicaments and certain medical uses of such photodynamic medicaments for treatment of human or animal tissue, wherein a primary active component of such medicaments is a halogenated xanthene.

U.S. Patent No. 8,557,298

"Medicaments for Chemotherapeutic Treatment of Disease",

Scott, Timothy C.; Dees, H. Craig; Wachter, Eric A.

A continuation-in-part of U.S. Patent No. 7,648,695, this patent provides detailed protection of the Company's investigational oncology drug PV-10, which is an injectable formulation of Rose Bengal.

U.S. Patent No. 8,530,675

"Process for the Synthesis of 4,5,6,7-tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-3H-spiro[isobenzofuran-1,9-xanthen]-3-one (Rose Bengal) and Related Xanthenes",

Singer, Jamie; Wachter, Eric A.; Scott, Timothy; Lutz, Marlon; Babiak, Kevin

This patent covers the process under which pharmaceutical grade Rose Bengal and related xanthenes are produced, reducing the formation of certain previously unknown transhalogenated impurities that currently exist in commercial grade Rose Bengal in uncontrolled amounts. The requirement to identify and control related substances is in accordance with International Conference on Harmonisation (ICH) guidelines for manufacture of API suitable for clinical trial material and commercial pharmaceutical use.

International Application No.: PCT/US2012/028412

"Combination of Local and Systemic Immunomodulative Therapies for Enhanced Treatment of Cancer",

Eagle, Craig J.; Dees, H. Craig; Wachter, Eric A.;Singer, Jamie

This patent covers a method of treatment of cancer that comprises administering a therapeutically effective amount of an intralesional chemoablative pharmaceutical composition in combination with a therapeutically effective amount of a systemic immunomodulatory anticancer agent. The systemic immunomodulatory anticancer agent comprises anti-CTLA-4 antibodies including ipilimumab and tremelimumab.

U.S. Patent No. 7,863,047

"Intracorporeal medicaments for photodynamic treatment of disease",

Dees, H. Craig; Scott, Timothy; Wachter, Eric A.; Fisher, Walter G.; Smolik, John

This patent covers the use of Rose Bengal and other halogenated xanthenes, new medical uses for such medicaments based on improved specificity for the desired target tissue to be treated, and methods for treatment using such medicaments along with photoactivation using visible wavelengths of light,

U.S. Patent No. 7,648,695

"Medicaments for Chemotherapeutic Treatment of Disease",

Dees, H. Craig; Scott, Timothy C.

This patent covers the use of Rose Bengal and other halogenated xanthenes as chemotherapeutic medicaments for treatment of disease based on the medicament's ability to provide selective, persistent accumulation in certain tissues.

U.S. Patent No. 7,427,389

"Diagnostic agents for positron emission imaging using radiolabeled halogenated xanthenes",

Scott, Timothy C.; Dees, H. Craig; Wachter, Eric A.

This patent covers the use of Rose Bengal and other halogenated xanthenes as a diagnostic agent for positron emission tomography (PET)..

U.S. Patent No. 7,402,299

"Intracorporeal medicaments for photodynamic treatment of disease",

Dees, H. Craig; Scott, Timothy C.; Wachter, Eric A.; Fisher, Walter G.; Smolik, John

This patent covers the use of Rose Bengal and other halogenated xanthenes as intracorporeal photodynamic therapeutic agents.

U.S. Patent No. 7,390,668

"Intracorporeal medicaments for photodynamic treatment of disease",

Dees, H. Craig; Scott, Timothy C.; Wachter, Eric A.; Fisher, Walter G.; Smolik, John

This patent covers the use of Rose Bengal and other halogenated xanthenes as intracorporeal photodynamic therapeutic agents.

U.S. Patent No. 7,384,623

"High energy phototherapeutic agents",

Dees, H. Craig; Scott, Timothy C.; Smolik, John T.; Wachter, Eric A.

This patent covers the use of Rose Bengal, halogenated xanthenes, halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive structures in diseased tissue, as radiosensitizer agents in the tratment and imaging of diseased tissue.

U.S. Patent No. 7,353,829

"Methods and apparatus for multi-photon photo-activation of therapeutic agents",

Wachter, Eric A.; Fisher, Walter G.; Smolik, John T.

This patent covers the use of Rose Bengal and other photo-active agents in treating plant or animal tissue by selectively activating the agent within a particular volume using multi-photon excitation.

U.S. Patent No. 7,346,387

"Methods for improved selectivity in photo-activation and detection of molecular diagnostic agents",

Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

This patent covers the use of Rose Bengal and other photo-active agents in imaging plant or animal tissue by selectively activating the agent within a particular volume via two-photon excitation of the agent using modulated light and selectively detecting the emitted modulated energy.

U.S. Patent No. 7,338,652

"Methods for positron emission imaging with radiolabeled halogenated xanthenes diagnostic agents",

Scott, Timothy C.; Dees, H. Craig; Wachter, Eric A.

This patent covers the use of radiolabeled Rose Bengal and other radiolabeled halogenated xanthenes as a diagnostic agent for positron emission tomography.

U.S. Patent No. 7,201,914

"Combination antiperspirant and antimicrobial composition",

Dees, H. Craig

This patent covers new medicaments and compositions having an antiperspirant agent and an antimicrobial agent and methods for control, prevention, amelioration, or treatment of perspiration and topical microbial contamination or infection of skin of the hands, feet, groin, face and other areas of the body.

U.S. Patent No. 7,036,516

"Treatment of pigmented tissues using optical energy",

Dees, H. Craig; Wachter, Eric A.

This patent covers the photobleaching or killing of pigmented tissues by photochemically activating an endogenous pigment within a particular volume of the tissue using two-photon excitation.

U.S. Patent No. 6,991,776

"Intracorporeal medicaments for high energy phototherapeutic treatment of disease",

Dees, H. Craig; Scott, Timothy C.; Wachter, Eric A.; Fisher, Walter G.; Smolik, John

This patent covers the use of Rose Bengal and other halogenated xanthenes as a radiosensitizer in the photodynamic treatment of disease using iomizing radiation.

U.S. Patent No. 6,986,740

"Ultrasound contrast using halogenated xanthenes",

Dees, H. Craig; Scott, Timothy C.; Wachter, Eric A.

This patent covers the use of Rose Bengal and other halogenated xanthenes as a contrast agent for ultrasound imaging.

U.S. Patent No. 6,541,223

"Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins",

Dees, H. Craig; Smolik, John

This patent protects a method for increasing production yield of viruses, viral proteins, and other related biological materials through enhanced control and stabilization of protein production via stress proteins and the resultant protein products, as well as methods for selection or engineering of cell lines yielding such enhanced stabilized products.

U.S. Patent No. 6,525,862

"Methods and apparatus for optical imaging",

Fisher, Walter G.; Wachter, Eric A.

This patent protects a method of using modulated light to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems.

U.S. Patent No. 6,519,076

"Methods and apparatus for optical imaging",

Fisher, Walter G.; Wachter, Eric A.

This patent protects a method of using modulated light to substantially improve detection limits in optical imaging, and to substantially improve the performance of various optical imaging systems.

U.S. Patent No. 6,495,360

"Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins",

Dees, H. Craig; Smolik, John

This patent protects an enhanced method of producing a viral agent via production of infected stressed eucaryotic cells.

U.S. Patent No. 6,493,570

"Method for improved imaging and photodynamic therapy",

Dees, H. Craig; Scott, Timothy

This patent protects the use of Rose Bengal and other halogenated xanthenes as a contrast or photodynamic therapy agent for computerized axial tomography, fluorography and magnetic resonance imaging.

U.S. Patent No. 6,468,777

"Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins",

Dees, H. Craig; Smolik, John

This patent protects amethod of enhancing functional recombinant product yield by inserting one or more stress protein expression vectors into a procaryotic cell line.

U.S. Patent No. 6,451,597

"Method for enhanced protein stabilization and for production of cell lines useful for production of such stabilized proteins",

Dees, H. Craig; Smolik, John

This patent protects a method for producing permissive cell lines exhibiting spontaneous recombination of a transfected DNA expression vector into host DNA.

U.S. Patent No. 6,331,286

"Methods for high energy phototherapeutics",

Dees, H. Craig; Scott, Timothy; Smolik, John T.; Wachter, Eric A.

This patent protects the use of Rose Bengal and other halogenated xanthenes as a radiosensitizer agent for treating tumor and cancer disease tissue by activation with high energy radiation.

U.S. Patent No. 6,042,603

"Method for improved selectivity in photo-activation of molecular agents",

Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

This patent protects aa method of treating a precise volume of plant or animal tissue by selectively activating a photo-active molecular agent such as Rose Bengal using simultaneous two-photon excitation.

U.S. Patent No. 5,998,597

"Method for improved selectivity in photo-activation of molecular agents",

Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

This patent protects aa method of treating a precise volume of plant or animal tissue by selectively activating a photo-active molecular agent such as Rose Bengal using simultaneous two-photon excitation.

U.S. Patent No. 5,832,931

"Method for improved selectivity in photo-activation and detection of molecular diagnostic agents",

Wachter, Eric A.; Fisher, Walter G.; Dees, H. Craig

This patent protects aa method of imaging a precise volume of plant or animal tissue by selectively activating a photo-active molecular agent such as Rose Bengal using simultaneous two-photon excitation and detecting the emitted energy.

U.S. Patent No. 5,829,448

"Method for improved selectivity in photo-activation of molecular agents",

Fisher, Walter G.; Wachter, Eric A.; Dees, H. Craig

This patent protects a method of treating a precise volume of plant or animal tissue by selectively activating a photo-active molecular agent such as Rose Bengal using simultaneous two-photon excitation.

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